REDDIE Second Progress Meeting at UNIPD: Advancing Collaboration for Real-World Data in Diabetes Research
The REDDIE project (Real-world Evidence for Decisions in Diabetes) is dedicated to enhancing randomised controlled trials by integrating real-world data from diabetes databases. Bringing together 16 partners from nine countries, the consortium convened for its second progress meeting in Padova, Italy, on 3-4 March, to review project advancements and outline the next steps for its third year. Approximately 40 consortium members participated both in person and online.
The meeting focused on leveraging real-world evidence (RWE) and synthetic data to strengthen clinical trial insights, fostering stakeholder engagement, and refining key methodologies. Each work package (WP) leader led dedicated workshops, facilitating discussions and innovative ideation.
Kickoff and Key Presentations
The event opened with a warm welcome from Project Coordinator Dr Julia Mader (Medical University of Graz) and Martina Radanović (RISE), who provided an overview of project management and set the course for upcoming milestones.
Monika Cigler (Medical University of Graz) presented the latest ethical recommendations, emphasising the importance of ethical considerations when working with patient data. Following this, the WP2 team, led by Dr Pratik Choudhary (Leicester Diabetes Centre), showcased progress on the Real-World Data (RWD) dashboard, discussing the identification of diabetes databases and the development of database guidelines.
Key Discussions on Synthetic Data and Methodologies
Subsequent sessions focused on WPs 3 and 5.
- WP3, led by Prof. Amanda Adler (University of Oxford), explored the role of synthetic data and preparations for the Mount Hood Challenge.
- WP5, led by the University of Padua, delved into advanced methodological approaches for integrating real-world and virtual evidence into clinical trials. Presentations were given by Martina Vettoretti, Enrico Longato, Erica Tavazzi, and Sara Poletto.
The first day concluded with insightful discussions on the project data analysis needs, followed by a networking dinner, where partners engaged in informal conversations and strengthened collaborations.
Day 2: Data Validation, National Registries & Exploitation
The second day commenced with WP4 updates, led by Prof. Christian Torp-Pedersen and his team at Nordsjællands Hospital Hillerød, focusing on validating RWE against Randomised Controlled Trial (RCT) evidence. Representatives from four national registries then shared progress on real-world data analysis across:
- Denmark (Katherine Kold Sørensen, Puriya Daniel Würtz Yazdanfard)
- Germany (Stephanie Lanzinger, Stefanie Schmid)
- Sweden (Jens Michelsen)
- United Kingdom (Manal Elzalabany, Gilberte Martine-Edith)
Following the data analysis presentations, Jakob Haardt (EURICE) led an interactive Exploitation Workshop, where partners collaborated on defining the project Key Exploitable Results (KERs). The final session, led by Dr Julia Mader, focused on stakeholder management activities and upcoming guidance deliverables. The meeting concluded with a wrap-up of key action points and areas for improvement.
Looking Ahead The meeting once again highlighted the value of in-person collaboration, enabling partners to efficiently address challenges, resolve open questions, and define clear next steps. The next REDDIE progress meeting is scheduled for 2026 in Croatia, hosted by Research and Innovation Services.
